Pathway Publications

Original Publications

  1. Dennis, M. D., Coleman, C. S., Berg, A., Jefferson, L. S., & Kimball, S. R. (2014). REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling. Science Signaling, 7(335), ra68.
  2. Dennis, M. D., Kimball, S. R., Fort, P. E., & Jefferson, L. S. (2015). Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents. The Journal of Biological Chemistry, 290(6), 3865–3874.
  3. Quang, D. X., Erdos, M. R., Parker, S. C. J., & Collins, F. S. (2015). Motif signatures in stretch enhancers are enriched for disease-associated genetic variants. Epigenetics & Chromatin, 8, 23.
  4. Krishnan, N., Krishnan, K., Connors, C. R., Choy, M. S., Page, R., Peti, W., … Tonks, N. K. (2015). PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. The Journal of Clinical Investigation, 125(8), 3163–3177.
  5. Krishnan, N., Koveal, D., Miller, D. H., Xue, B., Akshinthala, S. D., Kragelj, J., … Tonks, N. K. (2014). Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nature Chemical Biology, 10(7), 558–566.
  6. Yu, J., Zhang, Y., Ye, Y., DiSanto, R., Sun, W., Ranson, D., … Gu, Z. (2015). Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery. Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8260–8265.
  7. Di, J., Yao, S., Ye, Y., Cui, Z., Yu, J., Ghosh, T. K., … Gu, Z. (2015). Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots. ACS Nano, 9(9), 9407–9415.
  8. Di, J., Yu, J., Ye, Y., Ranson, D., Jindal, A., Gu, Z. Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles. Cellular and Molecular Bioengineering. 2015 (Cover Feature; Young Innovators Special Issue).
  9. Gao, M., Nguyen, T. T., Suckow, M. A., Wolter, W. R., Gooyit, M., Mobashery, S., & Chang, M. (2015). Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proceedings of the National Academy of Sciences of the United States of America, 112(49), 15226–15231.
  10. Moore, J. A., Miller, W. P., & Dennis, M. D. (2016). Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells. Cellular Signalling, 28(5), 384–390.
  11. Delong, T., Wiles, T. A., Baker, R. L., Bradley, B., Barbour, G., Reisdorph, R., … Haskins, K. (2016). Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science (New York, N.Y.), 351(6274), 711–714.
  12. Miller, W. P., Mihailescu, M. L., Yang, C., Barber, A. J., Kimball, S. R., Jefferson, L. S., & Dennis, M. D. (2016). The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction. Investigative Ophthalmology & Visual Science, 57(3), 1327–1337.
  13. Soares, M. A., Cohen, O. D., Low, Y. C., Sartor, R. A., Ellison, T., Anil, U., … Ceradini, D. J. (2016). Restoration of Nrf2 Signaling Normalizes the Regenerative Niche. Diabetes, 65(3), 633–646.
  14. Ye, Y., Yu, J., Wang, C., Nguyen, N.-Y., Walker, G. M., Buse, J. B., & Gu, Z. (2016). Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery. Advanced Materials (Deerfield Beach, Fla.), 28(16), 3115–3121.
  15. Szodoray, P., Stanford, S. M., Molberg, Ø., Munthe, L. A., Bottini, N., & Nakken, B. (2016). T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity. The Journal of Allergy and Clinical Immunology, 138(3), 839-851.e8.
  16. Scott, L. J., Erdos, M. R., Huyghe, J. R., Welch, R. P., Beck, A. T., Wolford, B. N., … Parker, S. C. J. (2016). The genetic regulatory signature of type 2 diabetes in human skeletal muscle. Nature Communications, 7, 11764.
  17. Powe, C. E., Allard, C., Battista, M.-C., Doyon, M., Bouchard, L., Ecker, J. L., … Hivert, M.-F. (2016). Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus. Diabetes Care, 39(6), 1052–1055.
  18. White, P. J., Lapworth, A. L., An, J., Wang, L., McGarrah, R. W., Stevens, R. D., … Newgard, C. B. (2016). Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export. Molecular Metabolism, 5(7), 538–551.
  19. Tang, J. C., Drokhlyansky, E., Etemad, B., Rudolph, S., Guo, B., Wang, S., … Cepko, C. L. (2016). Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. ELife, 5.
  20. Peck, B. C. E., Sincavage, J., Feinstein, S., Mah, A. T., Simmons, J. G., Lund, P. K., & Sethupathy, P. (2016). miR-30 Family Controls Proliferation and Differentiation of Intestinal Epithelial Cell Models by Directing a Broad Gene Expression Program That Includes SOX9 and the Ubiquitin Ligase Pathway. The Journal of Biological Chemistry, 291(31), 15975–15984.
  21. Zimmerman, C. A., Lin, Y.-C., Leib, D. E., Guo, L., Huey, E. L., Daly, G. E., … Knight, Z. A. (2016). Thirst neurons anticipate the homeostatic consequences of eating and drinking. Nature, 537(7622), 680–684.
  22. Fuchsberger, C., Flannick, J., Teslovich, T. M., Mahajan, A., Agarwala, V., Gaulton, K. J., … McCarthy, M. I. (2016). The genetic architecture of type 2 diabetes. Nature, 536(7614), 41–47.
  23. Leib, D. E., & Knight, Z. A. (2016). Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2. Cell Reports, 16(8), 2051–2052.
  24. Chen, Y., Lin, Y.-C., Zimmerman, C. A., Essner, R. A., & Knight, Z. A. (2016). Hunger neurons drive feeding through a sustained, positive reinforcement signal. ELife, 5.
  25. Kimball, S. R., Gordon, B. S., Moyer, J. E., Dennis, M. D., & Jefferson, L. S. (2016). Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation. Cellular Signalling, 28(8), 896–906.
  26. Kim, H.-E., Grant, A. R., Simic, M. S., Kohnz, R. A., Nomura, D. K., Durieux, J., … Dillin, A. (2016). Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response. Cell, 166(6), 1539-1552.e16.
  27. Tan, C. L., Cooke, E. K., Leib, D. E., Lin, Y.-C., Daly, G. E., Zimmerman, C. A., & Knight, Z. A. (2016). Warm-Sensitive Neurons that Control Body Temperature. Cell, 167(1), 47-59.e15.
  28. Gwiazda, K. S., Grier, A. E., Sahni, J., Burleigh, S. M., Martin, U., Yang, J. G., … Scharenberg, A. M. (2016). High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k “Helper” Proteins. Molecular Therapy: The Journal of the American Society of Gene Therapy, 24(9), 1570–1580.
  29. Cardenas, A., Allard, C., Doyon, M., Houseman, E. A., Bakulski, K. M., Perron, P., … Hivert, M.-F. (2016). Validation of a DNA methylation reference panel for the estimation of nucleated cells types in cord blood. Epigenetics, 11(11), 773–779.
  30. Babon, J. A. B., DeNicola, M. E., Blodgett, D. M., Crèvecoeur, I., Buttrick, T. S., Maehr, R., … Kent, S. C. (2016). Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nature Medicine, 22(12), 1482–1487.
  31. Cardenas, A., Allard, C., Doyon, M., Houseman, E. A., Bakulski, K. M., Perron, P., … Hivert, M.-F. (2016). Validation of a DNA methylation reference panel for the estimation of nucleated cells types in cord blood. Epigenetics, 11(11), 773–779.
  32. Black, A. J., Gordon, B. S., Dennis, M. D., Jefferson, L. S., & Kimball, S. R. (2016). Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum. Biochemistry and Biophysics Reports, 8, 296–301.
  33. Patenaude, J., Lacerte, G., Lacroix, M., Guillemette, L., Allard, C., Doyon, M., … Hivert, M.-F. (2017). Associations of Maternal Leptin with Neonatal Adiposity Differ according to Pregravid Weight. Neonatology, 111(4), 344–352.
  34. Hu, X., Yu, J., Qian, C., Lu, Y., Kahkoska, A. R., Xie, Z., … Gu, Z. (2017). H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery. ACS Nano, 11(1), 613–620.
  35. Douglass, J. D., Dorfman, M. D., Fasnacht, R., Shaffer, L. D., & Thaler, J. P. (2017). Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation. Molecular Metabolism, 6(4), 366–373.
  36. Miller, W. P., Ravi, S., Martin, T. D., Kimball, S. R., & Dennis, M. D. (2017). Activation of the Stress Response Kinase JNK (c-Jun N-terminal Kinase) Attenuates Insulin Action in Retina through a p70S6K1-dependent Mechanism. The Journal of Biological Chemistry, 292(5), 1591–1602.
  37. Choy, M. S., Li, Y., Machado, L. E. S. F., Kunze, M. B. A., Connors, C. R., Wei, X., … Peti, W. (2017). Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Molecular Cell, 65(4), 644-658.e5.
  38. Peck, B. C. E., Mah, A. T., Pitman, W. A., Ding, S., Lund, P. K., & Sethupathy, P. (2017). Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status. The Journal of Biological Chemistry, 292(7), 2586–2600.
  39. Dorfman, M. D., Krull, J. E., Douglass, J. D., Fasnacht, R., Lara-Lince, F., Meek, T. H., … Thaler, J. P. (2017). Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice. Nature Communications, 8, 14556.
  40. Varshney, A., Scott, L. J., Welch, R. P., Erdos, M. R., Chines, P. S., Narisu, N., … Stitzel, M. L. (2017). Genetic regulatory signatures underlying islet gene expression and type 2 diabetes. Proceedings of the National Academy of Sciences of the United States of America, 114(9), 2301–2306.
  41. Wiles, T. A., Delong, T., Baker, R. L., Bradley, B., Barbour, G., Powell, R. L., … Haskins, K. (2017). An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse. Journal of Autoimmunity, 78, 11–18.
  42. Dorfman, M. D., Krull, J. E., Scarlett, J. M., Guyenet, S. J., Sajan, M. P., Damian, V., … Thaler, J. P. (2017). Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes, 66(4), 920–934.
  43. Machado, L. E. S. F., Shen, T.-L., Page, R., & Peti, W. (2017). The KIM-family protein-tyrosine phosphatases use distinct reversible oxidation intermediates: Intramolecular or intermolecular disulfide bond formation. The Journal of Biological Chemistry, 292(21), 8786–8796.
  44. Wang, C., Ye, Y., Sun, W., Yu, J., Wang, J., Lawrence, D. S., … Gu, Z. (2017). Red Blood Cells for Glucose-Responsive Insulin Delivery. Advanced Materials (Deerfield Beach, Fla.), 29(18).
  45. Hivert, M.-F., Scholtens, D. M., Allard, C., Nodzenski, M., Bouchard, L., Brisson, D., … Lowe, W. L. (2017). Genetic determinants of adiponectin regulation revealed by pregnancy. Obesity (Silver Spring, Md.), 25(5), 935–944.
  46. Stanford, S. M., Aleshin, A. E., Zhang, V., Ardecky, R. J., Hedrick, M. P., Zou, J., … Bottini, N. (2017). Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nature Chemical Biology, 13(6), 624–632.
  47. Rabbani, P. S., Zhou, A., Borab, Z. M., Frezzo, J. A., Srivastava, N., More, H. T., … Ceradini, D. J. (2017). Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing. Biomaterials, 132, 1–15.
  48. Pereira, M. M. A., Mahú, I., Seixas, E., Martinéz-Sánchez, N., Kubasova, N., Pirzgalska, R. M., … Domingos, A. I. (2017). A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Nature Communications, 8, 14967.
  49. Valdearcos, M., Douglass, J. D., Robblee, M. M., Dorfman, M. D., Stifler, D. R., Bennett, M. L., … Koliwad, S. K. (2017). Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metabolism, 26(1), 185-197.e3.
  50. Riera, C. E., Tsaousidou, E., Halloran, J., Follett, P., Hahn, O., Pereira, M. M. A., … Dillin, A. (2017). The Sense of Smell Impacts Metabolic Health and Obesity. Cell Metabolism, 26(1), 198-211.e5.
  51. Flak, J. N., Arble, D., Pan, W., Patterson, C., Lanigan, T., Goforth, P. B., … Myers, M. G. (2017). A leptin-regulated circuit controls glucose mobilization during noxious stimuli. The Journal of Clinical Investigation, 127(8), 3103–3113.
  52. Wheeler, E., Leong, A., Liu, C.-T., Hivert, M.-F., Strawbridge, R. J., Podmore, C., … Meigs, J. B. (2017). Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Medicine, 14(9), e1002383.
  53. Yan, X., Wang, Z., Westberg-Rasmussen, S., Tarbier, M., Rathjen, T., Tattikota, S. G., … Poy, M. N. (2017). Differential Impact of Glucose Administered Intravenously and Orally on Circulating miR-375 Levels in Human Subjects. The Journal of Clinical Endocrinology and Metabolism, 102(10), 3749–3755.
  54. Sharp, G. C., Salas, L. A., Monnereau, C., Allard, C., Yousefi, P., Everson, T. M., … Relton, C. L. (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics, 26(20), 4067–4085.
  55. Beutler, L. R., Chen, Y., Ahn, J. S., Lin, Y.-C., Essner, R. A., & Knight, Z. A. (2017). Dynamics of Gut-Brain Communication Underlying Hunger. Neuron, 96(2), 461-475.e5.
  56. Choy, M. S., Swingle, M., D’Arcy, B., Abney, K., Rusin, S. F., Kettenbach, A. N., … Peti, W. (2017). PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors. Journal of the American Chemical Society, 139(49), 17703–17706.
  57. Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., … McCarthy, M. I. (2017). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, 170179.
  58. Machado, L. E. S. F., Page, R., & Peti, W. (2018). 1H, 15N and 13C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase. Biomolecular NMR Assignments, 12(1), 5–9.
  59. Miller, W. P., Yang, C., Mihailescu, M. L., Moore, J. A., Dai, W., Barber, A. J., & Dennis, M. D. (2018). Deletion of the Akt/mTORC1 Repressor REDD1 Prevents Visual Dysfunction in a Rodent Model of Type 1 Diabetes. Diabetes, 67(1), 110–119.
  60. Zillikens, M. C., Demissie, S., Hsu, Y.-H., Yerges-Armstrong, L. M., Chou, W.-C., Stolk, L., … Kiel, D. P. (2017). Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nature Communications, 8(1), 80.
  61. Roman, T. S., Cannon, M. E., Vadlamudi, S., Buchkovich, M. L., Wolford, B. N., Welch, R. P., … Mohlke, K. L. (2017). A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus. Diabetes, 66(9), 2521–2530.
  62. Leib, D. E., Zimmerman, C. A., Poormoghaddam, A., Huey, E. L., Ahn, J. S., Lin, Y.-C., … Knight, Z. A. (2017). The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement. Neuron, 96(6), 1272-1281.e4.
  63. Chen, Z., Wang, J., Sun, W., Archibong, E., Kahkoska, A. R., Zhang, X., … Gu, Z. (2018). Synthetic beta cells for fusion-mediated dynamic insulin secretion. Nature Chemical Biology, 14(1), 86–93.
  64. Nguyen, T. T., Ding, D., Wolter, W. R., Champion, M. M., Hesek, D., Lee, M., … Chang, M. (2018). Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers. European Journal of Pharmacology, 834, 77–83.
  65. White, P. J., McGarrah, R. W., Grimsrud, P. A., Tso, S.-C., Yang, W.-H., Haldeman, J. M., … Newgard, C. B. (2018). The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. Cell Metabolism, 27(6), 1281-1293.e7.
  66. Rabbani, P. S., Ellison, T., Waqas, B., Sultan, D., Abdou, S., David, J. A., … Ceradini, D. J. (2018). Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds. Diabetes Research and Clinical Practice, 139, 11–23.
  67. Fang, C., Zhong, H., Lin, Y., Chen, B., Han, M., Ren, H., … Li, J. (2018). Assessment of the cPAS-based BGISEQ-500 platform for metagenomic sequencing. GigaScience, 7(3), 1–8.
  68. Luber, J. M., Tierney, B. T., Cofer, E. M., Patel, C. J., & Kostic, A. D. (2018). Aether: leveraging linear programming for optimal cloud computing in genomics. Bioinformatics (Oxford, England), 34(9), 1565–1567.
  69. Pan, W., Adams, J. M., Allison, M. B., Patterson, C., Flak, J. N., Jones, J., … Myers, M. G. (2018). Essential Role for Hypothalamic Calcitonin Receptor‒Expressing Neurons in the Control of Food Intake by Leptin. Endocrinology, 159(4), 1860–1872.
  70. Meek, T. H., Matsen, M. E., Faber, C. L., Samstag, C. L., Damian, V., Nguyen, H. T., … Morton, G. J. (2018). In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus. Endocrinology, 159(4), 1585–1594.
  71. Kycia, I., Wolford, B. N., Huyghe, J. R., Fuchsberger, C., Vadlamudi, S., Kursawe, R., … Stitzel, M. L. (2018). A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression. American Journal of Human Genetics, 102(4), 620–635.
  72. Dai, W., Dierschke, S. K., Toro, A. L., & Dennis, M. D. (2018). Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression. Biochimica Et Biophysica Acta. Molecular Basis of Disease, 1864(12), 3568–3576.
  73. Dai, W., Miller, W. P., Toro, A. L., Black, A. J., Dierschke, S. K., Feehan, R. P., … Dennis, M. D. (2018). Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, fj201800413RR.
  74. Taylor, D. L., Knowles, D. A., Scott, L. J., Ramirez, A. H., Casale, F. P., Wolford, B. N., … Collins, F. S. (2018). Interactions between genetic variation and cellular environment in skeletal muscle gene expression. PloS One, 13(4), e0195788.
  75. Zou, L. S., Erdos, M. R., Taylor, D. L., Chines, P. S., Varshney, A., McDonnell Genome Institute, … Didion, J. P. (2018). BoostMe accurately predicts DNA methylation values in whole-genome bisulfite sequencing of multiple human tissues. BMC Genomics, 19(1), 390.
  76. Orchard, P., White, J. S., Thomas, P. E., Mychalowych, A., Kiseleva, A., Hensley, J., … Keegan, C. E. (2018). Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth’s short tail mice. Human Molecular Genetics.
  77. Powe, C. E., Nodzenski, M., Talbot, O., Allard, C., Briggs, C., Leya, M. V., … Hivert, M.-F. (2018). Genetic Determinants of Glycemic Traits and the Risk of Gestational Diabetes Mellitus. Diabetes.
  78. Cardenas, A., Gagné-Ouellet, V., Allard, C., Brisson, D., Perron, P., Bouchard, L., & Hivert, M.-F. (2018). Placental DNA Methylation Adaptation to Maternal Glycemic Response in Pregnancy. Diabetes, 67(8), 1673–1683.
  79. Keith, B. P., Barrow, J. B., Toyonaga, T., Kazgan, N., O’Connor, M. H., Shah, N. D., … Sheikh, S. Z. (2018). Colonic epithelial miR-31 associates with the development of Crohn’s phenotypes. JCI Insight, 3(19).
  80. Nguyen, T. T., Ding, D., Wolter, W. R., Pérez, R. L., Champion, M. M., Mahasenan, K. V., … Chang, M. (2018). Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. Journal of Medicinal Chemistry, 61(19), 8825–8837.
  81. Fujisaka, S., Avila-Pacheco, J., Soto, M., Kostic, A., Dreyfuss, J. M., Pan, H., … Kahn, C. R. (2018). Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites. Cell Reports, 22(11), 3072–3086.
  82. Kim, H., Theogarajan, L. S., & Pennathur, S. (2018). A repeatable and scalable fabrication method for sharp, hollow silicon microneedles. Journal of Micromechanics and Microengineering, 28(3), 035007.
  83. Khetan, S., Kursawe, R., Youn, A., Lawlor, N., Jillette, A., Marquez, E. J., … Stitzel, M. L. (2018). Type 2 Diabetes-Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets. Diabetes, 67(11), 2466–2477.
  84. Maeder, C. I., Kim, J.-I., Liang, X., Kaganovsky, K., Shen, A., Li, Q., … Shen, K. (2018). The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival. Cell, 174(6), 1436-1449.e20.
  85. Huang, C., Walker, E. M., Dadi, P. K., Hu, R., Xu, Y., Zhang, W., … Gu, G. (2018). Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Developmental Cell, 45(3), 347-361.e5.
  86. Lin, S., Nascimento, E. M., Gajera, C. R., Chen, L., Neuhöfer, P., Garbuzov, A., … Artandi, S. E. (2018). Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury. Nature, 556(7700), 244–248.
  87. Rabbani, P. S., Soares, M. A., Hameedi, S. G., Kadle, R. L., Mubasher, A., Kowzun, M., & Ceradini, D. J. (2018). Dysregulation of Nrf2/Keap1 Redox Pathway in Diabetes Affects Multipotency of Stromal Cells. Diabetes.
  88. Kantar, R. S., Rifkin, W. J., Wilson, S. C., David, J. A., Diaz-Siso, J. R., Levine, J. P., … Ceradini, D. J. (2018). Abdominal Panniculectomy: Determining the Impact of Diabetes on Complications and Risk Factors for Adverse Events. Plastic and Reconstructive Surgery, 142(4), 462e-471e.
  89. Baker, R. L., Jamison, B. L., Wiles, T. A., Lindsay, R. S., Barbour, G., Bradley, B., … Haskins, K. (2018). CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse. Diabetes, 67(9), 1836–1846.
  90. Kumar, G. S., Choy, M. S., Koveal, D. M., Lorinsky, M. K., Lyons, S. P., Kettenbach, A. N., … Peti, W. (2018). Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme. Science Advances, 4(11), eaau6044.
  91. Luo, S., Alves, J., Hardy, K., Wang, X., Monterosso, J., Xiang, A. H., & Page, K. A. (2018). Neural processing of food cues in pre-pubertal children. Pediatric Obesity.
  92. Wang, J., Ye, Y., Yu, J., Kahkoska, A. R., Zhang, X., Wang, C., … Gu, Z. (2018). Core-Shell Microneedle Gel for Self-Regulated Insulin Delivery. ACS Nano, 12(3), 2466–2473.
  93. Chen, G., Yu, J., & Gu, Z. (2018). Glucose-Responsive Microneedle Patches for Diabetes Treatment. Journal of Diabetes Science and Technology, 1932296818778607.
  94. Lawlor, N., Márquez, E. J., Orchard, P., Narisu, N., Shamim, M. S., Thibodeau, A., … Stitzel, M. L. (2019). Multiomic Profiling Identifies cis-Regulatory Networks Underlying Human Pancreatic β Cell Identity and Function. Cell Reports, 26(3), 788-801.e6.
  95. Kim, H., & Jaffrey, S. R. (2019). A Fluorogenic RNA-Based Sensor Activated by Metabolite-Induced RNA Dimerization. Cell Chemical Biology.
  96. Chen, Y., Essner, R. A., Kosar, S., Miller, O. H., Lin, Y.-C., Mesgarzadeh, S., & Knight, Z. A. (2019). Sustained NPY signaling enables AgRP neurons to drive feeding. ELife, 8.
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